Primus Anabolics

Quickstart – key points

Ipamorelin is a synthetic pentapeptide that acts as a selective growth hormone secretagogue by mimicking ghrelin at its receptor.

Its main advantage is its high specificity for stimulating GH release without causing increases in ACTH or cortisol, making it one of the safest secretagogues with minimal unwanted hormonal effects.

This educational protocol presents a once-daily subcutaneous approach using a practical dilution for precise measurements with an insulin syringe.

Reconstitution: Add 3.0 mL of bacteriostatic water → approximate concentration of 3.33 mg/mL.
Typical daily range: 100–300 mcg once daily (gradual titration recommended).
Easy measurement: At 3.33 mg/mL, 1 unit = 0.01 mL ≈ 33 mcg on a U-100 syringe.
Storage: Lyophilized: 2–8 °C or frozen at −20 °C; after reconstitution, refrigerate at 2–8 °C and use within ~4 weeks.

Dosage and Reconstitution Guide

Educational guide for reconstitution and daily dosing.

Standard / gradual approach (3.0 mL = ~3.33 mg/mL)

Weeks 1–2: 100 mcg → 3 units (0.03 mL)
Weeks 3–4: 150 mcg → 5 units (0.05 mL)
Weeks 5–8: 200 mcg → 6 units (0.06 mL)
Weeks 9–12: 250 mcg → 8 units (0.08 mL)

Frequency: Subcutaneous injection once daily, ideally 30–60 minutes before bed and on an empty stomach to enhance natural GH release. For doses ≤10 units, consider 30 or 50-unit syringes for greater precision.

Reconstitution Steps

Draw 3.0 mL of bacteriostatic water with a sterile syringe.
Inject slowly down the side of the vial; avoid foaming.
Gently swirl until dissolved (do not shake forcefully).
Label and refrigerate at 2–8 °C, protected from light.

Important: This content is educational only and does not constitute medical advice.

Required Supplies

Plan based on a daily 8–16 week protocol with gradual titration.

Peptide vials (Ipamorelin, 10 mg):

8 weeks ≈ 2 vials
12 weeks ≈ 2–3 vials
16 weeks ≈ 3 vials

Insulin syringes (U-100):

Per week: 7
8 weeks: 56
12 weeks: 84
16 weeks: 112

Bacteriostatic water (10 mL):

8 weeks: 6 mL → 1 bottle
12 weeks: 6–9 mL → 1 bottle
16 weeks: 9 mL → 1 bottle

Alcohol wipes:

Per week: 14
8 weeks: 112 → recommend 2 boxes
12 weeks: 168 → recommend 2 boxes
16 weeks: 224 → recommend 3 boxes

Protocol Overview

Objective: Stimulate natural growth hormone release to support muscle growth, fat metabolism, and recovery.
Duration: 8–12 weeks (optional up to 16 weeks) followed by a 2–4 week rest.
Dose range: 100–300 mcg daily with gradual titration (200 mcg is a common intermediate dose).
Reconstitution: 3.0 mL per 10 mg vial (~3.33 mg/mL).
Storage: Lyophilized refrigerated or frozen; reconstituted refrigerated; use within ~4 weeks.

Dosing Protocol

Start: 100 mcg daily; increase by ~50 mcg every 1–2 weeks according to tolerance.
Goal: 200–250 mcg daily in weeks 5–12.
Frequency: Once daily, preferably before bed.
Cycle duration: 8–12 weeks; optional up to 16 weeks, followed by rest.
Schedule: Recommended nighttime use; rotate injection sites.

Storage Instructions

Lyophilized: 2–8 °C short-term or −20 °C long-term; keep dry and dark.
Reconstituted: 2–8 °C; use within ~4 weeks; aliquots can be frozen avoiding repeated cycles.
Let the vial reach room temperature before opening to avoid condensation.

Important Notes

Use new sterile syringes for every injection.
Rotate sites (abdomen, thighs, arms) to avoid irritation.
Inject slowly and wait before removing the needle.
Record dose and injection sites.
It has a short half-life (~1.5–2.5 hours); consistency is key.

How it works

Ipamorelin binds to the GHSR-1a receptor and stimulates the pituitary gland to release growth hormone in a pulsatile manner. Unlike other peptides, it is highly selective and does not significantly increase cortisol, ACTH, or prolactin.

After injection, GH levels peak in about 40 minutes and return to normal in 2–3 hours. This short, pulsatile pattern makes it suitable for daily administration. It has also been observed that it can improve gastrointestinal motility and accelerate gastric emptying.

Potential Benefits and Side Effects

Increase in muscle mass and improvement in recovery.
Improvement in fat metabolism.
High selectivity with few hormonal side effects.
Possible improvement in digestion.
Generally well tolerated.
Possible mild reactions at the injection point.
Rare cases of water retention or increased appetite.

Lifestyle Factors

High-protein diet to support muscle growth.
Strength training + cardio.
Sleep 7–9 hours (key for GH).
Stress management (cortisol reduces GH).
Use on an empty stomach to maximize effect.

Injection Technique

Clean hands and surface.
Disinfect vial and injection zone.
Load the syringe and remove air.
Inject into abdomen, thigh or arm.
Pinch the skin and insert at 45–90°.
Do not aspirate; inject slowly.
Remove the needle and apply gentle pressure.
Rotate sites to avoid irritation.
Dispose of the syringe correctly.